Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation
Description
Schematic illustration of bioengineered vessel grafts generation using human induced pluripotent stem cells-derived SMCs through CPC lineage. TGFBR1+/+ and TGFBR1A230T/+ M-SMCs were seeded onto biodegradable PGA-based mesh and cultured for 8 weeks in vitro.
Acknowledgements
References
Yang Y, Feng H, Tang Y, Wang Z, Qiu P, Huang X, Chang L, Zhang J, Chen YE, Mizrak D, Yang B. Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects. Science Translational Medicine. 2024 May 8;16(746):eadg6298.
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