Bacteriophage (phage) Steering - example
Description
Bacterial cell resistant to drug through activation of drug efflux pump. Phage recognizes binding site on bacterial drug efflux protein and injects genome, leading to cell lysis (A). Bacterial cell develops resistance to phage through mutation (depicted in green) in gene which encodes phage binding site on efflux protein, leading to inactivation of protein, inability to remove drug from cell, and susceptibility to drug (B).
Acknowledgements
References
Chan, B. K., Sistrom, M., Wertz, J. E., Kortright, K. E., Narayan, D., & Turner, P. E. (2016). Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa. Scientific Reports, 6(1). https://doi.org/10.1038/srep26717
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