B Regulatory Cell Surface Receptors Influence IL10-Mediated Immune Tolerance

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Binding of CD38 ligand (CD38L) to CD38 and IL10 to the IL10 receptor (IL10R) on B cells leads to increased expression of IL10 associated genes via the activation of the respective CD38/Syk/ERK/sp1 and IL10/IL10R/JAK/STAT3 pathways. These lead to the production of enhanced anti-inflammatory cytokines as well as the survival family of proteins, Bcl2. In addition, IgM and BAFF/APRIL binding to the B cell receptor and BCMA/TACI, respectively, leads to the activation of Syk/PI3K/AKT and Blimp-1/XBP-1, culminating in the activation of STAT3 and increased IL10 gene expression.

Acknowledgements

References

Domínguez-Pantoja M etal.,. (2017) CD38 protein deficiency induces autoimmune characteristics and its activation enhances IL-10 production by regulatory B cells. Scand J Immunol. https://www.ncbi.nlm.nih.gov/pubmed/29603313 Sarvaria, A et al.,. (2017) B cell regulation in cancer and anti-tumor immunity. Cell Mol Immunol. https://doi.org/10.1038/cmi.2017.35 Sepúlveda, P et al.,. (2007) BCL-2 expression is mainly regulated by JAK/STAT3 pathway in human CD34+ hematopoietic cells. Cell Death Differ . https://doi.org/10.1038/sj.cdd.4402007

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