Avesicular Entosis
Description
An endocytosis process, allowing the infiltration of autoreactive CD8+ T cells into BEC which are lining the bile duct. CD8+ T cell undergoes actin remodelling which protrudes out and migrates towards BEC. The invasion of CD8+ T cells requires actomyosin contractile activity, as well as E-cadherin-β-catenin interactions. The T cell stays active inside the BEC, showing a larger and more eccentric state while not being surrounded by a secondary vesicle. Some internalised T cells may be released.
Acknowledgements
References
Davies, S. P., Ronca, V., Wootton, G. E., Krajewska, N. M., Bozward, A. G., Fiancette, R., Patten, D. A., Yankouskaya, K., Reynolds, G. M., Pat, S., Osei-Bordom, D. C., Richardson, N., Grover, L. M., Weston, C. J., & Oo, Y. H. (2024). Expression of E-cadherin by CD8(+) T cells promotes their invasion into biliary epithelial cells. Nat Commun, 15(1), 853. https://doi.org/10.1038/s41467-024-44910-2
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