Apical Periodontitis Immunology

Description

Cellular components and mediators play crucial roles in the inflammation and bone metabolism associated with apical periodontitis. Cytokines like IL-1β, IL-1α, IL-6, TNF-α, and INF-γ regulates inflammation, while RANK, RANKL, and OPG are pivotal for bone metabolism regulation in this condition. IL, Interleukin; TNF, Tumor necrosis factor; INF, Interferon; RANK, Receptor Activator of Nuclear Factor κB; RANKL, Receptor Activator of Nuclear Factor κB Ligand; OPG, Osteoprotegerin.

Acknowledgements

References

Petean IBF, Silva-Sousa AC, Cronenbold TJ, Mazzi-Chaves JF, Silva LABD, Segato RAB, Castro GAP, Kuchler EC, Paula-Silva FWG, Sousa-Neto MD. Genetic, Cellular and Molecular Aspects involved in Apical Periodontitis. Braz Dent J. 2022 Jul-Aug;33(4):1-11. doi: 10.1590/0103-6440202205113. PMID: 36043561; PMCID: PMC9645190. Cavalla F, Letra A, Silva RM, Garlet GP. Determinants of Periodontal/Periapical Lesion Stability and Progression. J Dent Res. 2021 Jan;100(1):29-36. doi: 10.1177/0022034520952341. Epub 2020 Aug 31. PMID: 32866421. Alvarez C, Monasterio G, Cavalla F, Córdova LA, Hernández M, Heymann D, Garlet GP, Sorsa T, Pärnänen P, Lee HM, Golub LM, Vernal R, Kantarci A. Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms. Front Immunol. 2019 Jul 18;10:1664. doi: 10.3389/fimmu.2019.01664. PMID: 31379856; PMCID: PMC6657671.

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