Antimicrobial Resistance Mechanisms of Bacteria
Description
A mutation in the gene encoding the drug target results in the inability of the drug to bind and enter bacterial cell (A). A gene encoding an enzyme inactivates the drug, leading to inability to kill bacterial cell (B). A mutation in or increased expression of a drug efflux gene increases rate of active efflux of drug out of bacterial cell (C).
Acknowledgements
References
Reygaert, W. C. (2018). An overview of the antimicrobial resistance mechanisms of bacteria. AIMS Microbiology, 4(3), 482–501. https://doi.org/10.3934/microbiol.2018.3.482
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