Antibacterial mechanism of Ag+ ions on Gram-negative bacteria
Description
The Ag+ bind to sulfhydryl(thiol) groups in amino acids and inactivate enzymes or proteins, leading to cell death. Ag+ inactivates enzymes responsible for peptidoglycan synthesis, which prevents cell duplication. Further, the release of iron from organic molecules damaged by Ag+, causes the subsequent formation of reactive oxygen species, leading to protein, enzyme, or DNA disruption and cell death. The Ag+ tend to accumulate in periplasmatic space, leading to protein and enzyme inactivation.
Acknowledgements
References
T. Ivankovic, H. Turk, J. Hrenovic, Z. Schauperl, M. Ivankovic, A. Ressler, Antibacterial activity of silver doped hydroxyapatite toward multidrug-resistant clinical isolates of Acinetobacter baumannii, Journal of Hazardous Materials 458 (2023) 131867.
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