Anti-neutrophil Cytoplasmic Antibody (ANCA)-associated Vasculitis
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
A pro-inflammatory environment (1) initiates the production of ANCA by plasma cells (2) as well as priming of neutrophils through cytokines (3). ANCA bind to myeloperoxidase (MPO) and proteinase 3 (PR3) on the surface of primed neutrophils (4) causing the release of reactive oxygen species (ROS) and lytic enzymes and excessive activation (5). Subsequent release of neutrophil extracellular traps (NETs) (6) causes the development of ANCA vasculitis with vessel inflammation and haemorrhages (8).
Acknowledgements
References
Nakazawa et. al.. (2019) Pathogenesis and therapeutic interventions for ANCA-associated vasculitis. Nature Reviews Rheumatology. https://www.nature.com/articles/s41584-018-0145-y
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