Angiotensin converting enzyme (ACE) degradation of Substance P (SP)

Description

Angiotensin converting enzyme (ACE) has two cleave pathways for the peptide Substance P (SP). Along one arm, the first cleavage generates SP 1-8 and the tripeptide Gly-Leu-Met while the second cleavage generates the dipeptides Arg-Pro, Lys-Pro, Gln-Gln, and Phe-Phe and the tripeptide Gly-Leu-Met. The second arm first generates SP 1-9 and the dipeptide Leu-Met while the second cleavage generates SP 1-5 and the dipeptides Gln-Phe, Phe-Gly, and Leu-Met.

Acknowledgements

References

Thiele, E. A., Strittmatter, S. M., & Snyder, S. H. (1985). Substance K and substance P as possible endogenous substrates of angiotensin converting enzyme in the brain. Biochemical and biophysical research communications, 128(1), 317-324. Piercey, M. F., Dobry, P. J., Einspahr, F. J., Schroeder, L. A., & Masiques, N. (1982). Use of substance P fragments to differentiate substance P receptors of different tissues. Regulatory Peptides, 3(5-6), 337-349.

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