An In-depth Look into the Structure of the SARS-CoV2 Spike Glycoprotein
Description
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The S glycoprotein of the newly discovered SARS-CoV2 is composed of two subunits, S1 and S2, and is commonly represented as a sword-like spike. The real structure of this protein, however, can be observed using crystallography. The Protein Data Bank (PDB) model of this glycoprotein reveals how the subunits are comprised of different regions that are fundamental to the infection process. S1 and S2 are linked together by a polybasic amino acid bridge, which may be important in studying viral targeting.
Acknowledgements
References
Andersen K.G., et al.. (2020) The proximal origin of SARS-CoV-2. Nature Medicine. https://www.nature.com/articles/s41591-020-0820-9#citeas
Jian S. et.al.. (2020) Cell entry mechanisms of SARS-CoV-2. PNAS. https://www.pnas.org/content/117/21/11727
Walls, A.C. et al.. (2020) Structure of the SARS-CoV-2 spike glycoprotein (closed state). PDB. https://www.wwpdb.org/pdb?id=pdb_00006vxx
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