Amyloidogenic Pathway
Description
In the amyloidogenic pathway, amyloid precursor protein is first cleaved by β-secretase and subsequently cleaved by γ-secretase to generate Aβ peptides. The accumulation and aggregation of Aβ peptides results in neurotoxic amyloid plaques.
Acknowledgements
References
Patterson, C., Feightner, J. W., Garcia, A., Hsiung, G.-Y. R., MacKnight, C., & Sadovnick, A. D. (2008). Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease. CMAJ, 178(5), 548–556. https://doi.org/10.1503/cmaj.070796
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