Adoptive Cell Therapy: Cultivating, Growing, Screening, and Infusing TIL

Description

A depiction of the clinical process of patients undergoing the TIL protocol. Patient's with metastatic cancer have tumor resected, which is then dissected into many pieces. These tumor fragments are then split between the TIL lab for patient treatment production, and scientists that screen the TIL for neoantigen reactivity.

Acknowledgements

References

Stevanović S, Helman SR, Wunderlich JR, Langhan MM, Doran SL, Kwong MLM, Somerville RPT, Klebanoff CA, Kammula US, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS. A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers. Clin Cancer Res. 2019 Mar 1;25(5):1486-1493. doi: 10.1158/1078-0432.CCR-18-2722. Epub 2018 Dec 5. PMID: 30518633; PMCID: PMC6397671.

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