Activation of T-cells
Description
Three signals are required for the activation of T-cells. The first signal is comprised of the recognition of the peptide-MHC complex by the T-cell receptor (TCR). The second signal is the interaction between the CD28 molecule present on the surface of the T-cell and the B7 molecule expressed by the antigen-presenting cell (APC). The third signal is the costimulatory cytokine secreted by the APC, which binds to the cytokine receptor present on the surface of the T-cell.
Acknowledgements
References
Day, Michael., Schultz, Ronald. (2011). Veterinary Immunology: Principles and Practice. Manson Publishing.
Bennett, J. E., Dolin, R., & Blaser, M. J. (2020). Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Elsevier.
Sharpe, A. H., & Freeman, G. J. (2002). The B7–CD28 superfamily. Nature Reviews Immunology, 2(2), 116–126. https://doi.org/10.1038/nri727
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