A Closer Look Into the Extracellular Matrix (ECM) Proteome

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The extracellular matrix (ECM) relevance is growing in the field of proteomics, but many studies characterize it only from non-enriched samples. The removal of cells, known as decellularization, is the most common way of enriching for the extracellular fraction. Due to the low abundance of many ECM proteins, this technique improves detection by depleting intracellular contaminants, even though some soluble ECM proteins get removed in the process.

Acknowledgements

References

Wilson, R.. (2010) The extracellular matrix: an underexplored but important proteome. Expert reviews proteomics. https://www.tandfonline.com/doi/full/10.1586/epr.10.93 Naba, A. et. al. (2012) The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices. Molecular & Cellular Proteomics. https://www.mcponline.org/content/11/4/M111.014647 Li, Q. et. al. (2015) Proteomic Analysis of Naturally-Sourced Biological Scaffolds. Biomaterials. https://pubmed.ncbi.nlm.nih.gov/26476196/ Krasny, L. et. al. (2016) Comparative proteomic assessment of matrisome enrichment methodologies. Biochemical Journal. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095915/

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