Unbalanced Processing of 3'UTR Activates Oncogenes in Cancer
Description
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3’Untranslated Regions (UTRs) of oncogenes with two PolyAdenylation Sites (PASs) can be alternatively cleaved and polyadenylated at proximal (p) or distal (d) PAS, resulting in a short or long isoform respectively. Protein expression from the long isoform is limited by miRNA targeting. Normally, 3’UTRs are equally processed at both PASs, resulting in balanced protein production. In cancer, 3’UTRs are preferentially processed at pPAS, causing protein overexpression underlying oncogene activation.
Acknowledgements
References
Mayr and Bartel. (2009) Widespread Shortening of 30UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells. Cell. https://doi.org/10.1016/j.cell.2009.06.016
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