miR-149 Inhibits Lung Metastasis via CSF1
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
miR-149 downregulation in triple-negative breast cancer (TNBC) promotes tumor progression and metastasis by increasing colony-stimulating factor-1 (CSF1)-dependent recruitment and M2 polarization of tumor-associated macrophages (TAMs), and by enhancing reciprocal epidermal growth factor (EGF), amphiregulin (AREG) / CSF1 signaling between cancer cells and TAMs.
Acknowledgements
References
Sanchez-Gonzalez, I. (2020) miR-149 Suppresses Breast Cancer Metastasis by Blocking Paracrine Interactions with Macrophages. Cancer Research. https://cancerres.aacrjournals.org/content/80/6/1330
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