M2-like Macrophages Promote Colorectal Cancer Cell Invasion through CCL18
Description
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Human colorectal cancer decellularized extracellular matrix (ECM), derived from cancer patients’ surgical resections, polarizes monocytes towards anti-inflammatory M2-like macrophages with increased expression of CCL18. The presence of this immunosuppressive chemokine is crucial for colorectal cancer cells invasion, and its increased expression at the tumor invasive front is correlated with advanced tumor staging.
Acknowledgements
References
Pinto, M.L.. (2017) Decellularized human colorectal cancer matrices polarize macrophages towards an anti-inflammatory phenotype promoting cancer cell invasion via CCL18. Biomaterials.
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