Iodide-Doped Gold Nanoparticles to Measure Oxidative Stress Using Photo-Acoustic Imaging (PA)
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Gold nanorods are commonly used as photoacoustic (PA) contrast agents. Previously Au/Ag activatable nanoparticle has been reported to respond to reactive oxygen and nitrogen species (RONS) using PA. RONS can selectively etch off the shell while leaving the gold core intact. The etching results in reactivation of the PA signal. Iodide-doping of silver increases sensitivity to RONS, thus physiologically relevant levels can be detected in a mouse model.
Acknowledgements
References
Mantri, Y., Davidi B. et al. Iodide-doped precious metal nanoparticles: measuring oxidative stress in vivo via photoacoustic imaging. Nanoscale (2020). 10.1039/D0NR03047C
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