FBXL17 Loss of Function Leads to Increased Global O-GlcNAcylation in Breast Cancer
Description
The F-box protein encoded by FBXL17 is rearranged in breast cancer. Resulting loss of function in Fbxl17. Uap1, an enzyme involved in O-GlcNAcylation, could interact with Fbxl17. Fbxl17 binds to UAP1 directly and inhibits its phosphorylation, which regulates UAP1 activity. Knockdown of Fbxl17 expression elevated O-GlcNAcylation in breast cancer cells, arguing for a functional role for Fbxl17 in this metabolic pathway.
Acknowledgements
References
Mason, B., Flach, S., Teixeira, F. R., Manzano Garcia, R., Rueda, O. M., Abraham, J. E., Caldas, C., Edwards, P., & Laman, H. (2020). Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation. Cellular and molecular life sciences : CMLS, 77(13), 2605–2620. https://doi.org/10.1007/s00018-019-03306-y
Get started with this template for freeDon’t start from scratch.
Create professional scientific illustrations quickly and easily, even without any design expertise
- Get started with a huge library of editable icons and templates such as common biological pathways, anatomy, or genetics.
- Create figures that effectively communicate your research in half the time using our editable icons.
- Use our PDB tool to quickly generate and customize protein structures
.gif)
