Extracellular Matrix (ECM) Sequestering Peptides
Description
Synthetic matrices offer a high degree of control and flexibility in mimicking the extracellular matrix (ECM) functions of native tissue. However, they are inert and inefficient at retaining cell-secreted extracellular molecules.
Through functionalization of degradable poly(ethylene glycol) hydrogels with ECM-sequestering peptides, the synthetic matrices can be made more effective at recreating cell-matrix interactions, and thus more capable of recapitulating the native ECM composition.
Acknowledgements
References
Tomaszewski CE, DiLillo KM, Baker BM, Arnold KB, Shikanov A. Sequestered cell-secreted extracellular matrix proteins improve murine folliculogenesis and oocyte maturation for fertility preservation. Acta Biomater. 2021 Sep 15;132:313-324. doi: 10.1016/j.actbio.2021.03.041. Epub 2021 Mar 22. PMID: 33766798; PMCID: PMC8434940.
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