Exploring Potential Renal Effects of Dipeptidyl-Peptidase-4 Inhibitors (DPP-4is)
Description
Dipeptidyl-peptidase-4 inhibitors (DPP-4is) are non-insulin glucose-lowering agents, belonging to the incretin family, able to improve glycaemic control with a favorable safety profile. They are associated with a low risk of hypoglycemia, no weight gain, and good tolerability in patients with chronic kidney disease. Some experimental and clinical studies suggest that DPP-4is may exert significant pleiotropic effects, in particular on kidneys, but data from clinical trials are still controversial.
Acknowledgements
References
Coppolino, G., Leporini, C., Rivoli, L., Ursini, F., di Paola, E. D., Cernaro, V., Arturi, F., Bolignano, D., Russo, E., De Sarro, G., & Andreucci, M. (2018). Exploring the effects of DPP-4 inhibitors on the kidney from the bench to clinical trials. Pharmacological research, 129, 274–294. https://doi.org/10.1016/j.phrs.2017.12.001
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