DNA Methylation Levels During Mammalian Development
Description
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During prenatal development, highly methylated primordial germ cells (PGCs) undergo methylation before gametes are re-methylated in a sex-specific manner. Following fertilization, methylation of the inherited oocyte and sperm genomes are differentially erased during preimplantation embryo development. Imprinted genes and intracisternal A-type particles, however, remain highly methylated. New methylation is established associated with cell differentiation.
Acknowledgements
References
Smallwood, S.A. et. al.. (2012) De Novo DNA Methylation: A Germ Cell Perspective. Trends in Genetics. https://www.cell.com/trends/genetics/fulltext/S0168-9525(11)00158-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0168952511001582%3Fshowall%3Dtrue
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